Fig. 6.
Cytokine-induced neutrophil chemokine (CINC)-1 blockade prevents transforming growth factor (TGF)-β1–mediated downregulation of β2-adrenergic receptor (β2AR) on rat type II alveolar cells. Pretreatment with a blocking antibody to CINC-1 but not with its isotype control antibody prevents TGF-β1–mediated decrease in β2AR cell membrane density, measured by saturation binding experiments ([125I] iodocyanopindolol, [125I]-ICYP) (n = 6). For all experiments, the results are means ± SD; *P < 0.05 from controls. Cont = control; IgG = immunoglobulin G.