Fig. 6.
Effects of sodium thiosulfate (STS) on lipopolysaccharide (LPS) or tumor necrosis factor-α (TNFα)–induced cytokine production in human umbilical vein endothelial cells (HUVECs) and human lung microvascular endothelial cells (HMVEC-L). Interleukin (IL)-6 levels in HUVEC (A) and HMVEC-L (B) culture medium incubated with LPS or TNFα for 20 h with or without varying concentrations of STS. ***P < 0.001 versus control. ###P < 0.001, ##P < 0.01, #P < 0.05 versus LPS or TNFα; one-way ANOVA Bonferroni posttest, mean ± SD. (C) IL-8 levels in HUVEC culture medium incubated with LPS or TNFα for 20 h with or without 20 mM STS. ***P < 0.001; two-way ANOVA Bonferroni posttest, mean ± SD. Numbers in bars represent the sample size.

Effects of sodium thiosulfate (STS) on lipopolysaccharide (LPS) or tumor necrosis factor-α (TNFα)–induced cytokine production in human umbilical vein endothelial cells (HUVECs) and human lung microvascular endothelial cells (HMVEC-L). Interleukin (IL)-6 levels in HUVEC (A) and HMVEC-L (B) culture medium incubated with LPS or TNFα for 20 h with or without varying concentrations of STS. ***P < 0.001 versus control. ###P < 0.001, ##P < 0.01, #P < 0.05 versus LPS or TNFα; one-way ANOVA Bonferroni posttest, mean ± SD. (C) IL-8 levels in HUVEC culture medium incubated with LPS or TNFα for 20 h with or without 20 mM STS. ***P < 0.001; two-way ANOVA Bonferroni posttest, mean ± SD. Numbers in bars represent the sample size.

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