Fig. 4.
Toll-like receptor 4 (TLR4)–deficient mice develop worse kidney and liver injury during low-grade sepsis. Mice were subjected to sham or cecum ligation and puncture (CLP) surgery. Serum was collected 24 h after surgery. Each error bar represents the mean ± standard error. Two-way ANOVA was used for statistical analysis and Bonferroni post hoc tests were applied for difference between groups. *P ≤ 0.05, **P < 0.01, ***P < 0.001; n = 3 in sham group, n = 7 in CLP group. ALT = alanine aminotransferase; AST = aspartate aminotransferase; BUN = blood urea nitrogen; N.D. = not detectable; WT = wild type.