Fig. 2.
Paw edema after incision and complete Freund’s adjuvant (CFA) injection. (A) Time courses of changes in paw thickness in α-calcitonin gene–related peptide (αCGRP) knockout mice and wild-type (WT) mice before and after incision. (B) Time courses of changes in paw thickness in αCGRP knockout mice and WT mice before and after CFA injection. Paw thickness significantly increased from 4 h after incision and CFA injection and thereafter both in αCGRP knockout mice and WT mice compared with that before incision and CFA injection. However, there were no significant differences in paw thickness between αCGRP knockout mice and WT mice after incision and CFA injection. n = 5 or 6 in each group. Data are expressed as means ± SDs. *P < 0.05 compared with 0 h (baseline). Contralateral (contra.) = paw on the contralateral side to incision or CFA injection; ipsilateral (ipsi.) = paw on the ipsilateral side to incision or CFA injection.