Time course of membrane lung carbon dioxide removal (VCO₂ML, A), arterial blood lactate (B), arterial pH (C), erythrocyte adenosine triphosphate (erythrocytes ATP, D), and erythrocyte acetyl cholinesterase (erythrocytes AChE, E). Statistical analysis was performed only on the eight pigs subjected to acidification. *P < 0.001 versus “1 h I”; #P < 0.001 versus “baseline II” and “baseline III”; §P < 0.001 versus “baseline I”; &P < 0.001 versus “baseline I,” “baseline II,” and “baseline III.”