Effects of sevoflurane exposure on hypothalamic and hippocampal potassium ion-chloride ion cotransporter KCC2 gene (Kcc2) and sodium ion-potassium ion-chloride ion cotransporter NKCC1 gene (Nkcc1) mRNA in F0 rats. (A–H) Shown are the respective levels of Nkcc1 mRNA and Kcc2 mRNA in the hypothalamus of F0 males (A and B) and F0 females (C and D) and in the hippocampus of F0 males (E and F) and F0 females (G and H). Data normalized against control are means ± SD from 6 rats per group (n = 5, female hippocampus in sevoflurane group). *P < 0.05 versus Control.