Fig. 1.
Toll-like receptor 7 (TLR7)–deficient mice have improved survival and attenuated acute kidney injury after polymicrobial sepsis. (A) Survival rate of wild-type (WT) and TLR7−/− mice during sepsis. Mice were subjected to cecal ligation and puncture (CLP) surgery and observed for survival for up to 11 days. **P < 0.01, n = 27 in WT and TLR7−/− group. (B) Rectal temperature at 24 h after CLP surgery. ***P < 0.001, ****P < 0.0001 versus sham group. Unequal variance t test, n = 11 per group. (C) Kidney neutrophil gelatinase–associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) mRNA expression in WT and TLR7−/− mice at 24 h postprocedure. *P < 0.05, **P < 0.01, ****P < 0.001 versus sham group. Unequal variance t test. N = 4 to 8 per group. Each bar represents mean ± SD.