Fig. 4.
![Isoflurane modulates sub-threshold transient and persistent currents. (A) Representative currents recorded by a stair ramp protocol. Transient (INaT) and state-steady persistent (INaP) currents at each potential were calculated. (B) Sample of initial part of recording. INaT was inhibited by isoflurane at a clinically relevant concentration (0.42 mM, ~1.6 minimum alveolar concentration [MAC], n = 8, P = 0.047, and P = 0.011) at potentials of −50 and −45 mV (C), whereas INaP was inhibited at a potential of −60 mV (D, n = 9, P = 0.044). Data are mean ± SD. *P < 0.05 by two-way ANOVA. CTL, control; ISO, isoflurane.](https://asa2.silverchair-cdn.com/asa2/content_public/journal/anesthesiology/131/1/10.1097_aln.0000000000002753/3/23ff04.png?Expires=1716484205&Signature=Rs8JH6KwuzXeYvhR51XhoqA5ptX9JMbBzV-lQAN~9aaXJ2-Sl0yBCf~s4eB3osmxRgDp6QmeumYH47Rc1vbJ0w~d8ohoTLabK~rpZxmxccqcLS9IHl~iGESvlRZLyQr9gyM8lyr3phGrh7EtLzOdovTgqEXAwe5EiJDuSNEoiWTPet2qiqNAluLt1UqNHISLG1c6PLVOz2bc-05r4mtcGonUldISl8XqA300G3QTyLvtRaaGvT~GRusYZ9c7cJXGb4rwRGEO2Pf4xY73mNYtPKf3zB6M2fc-l-VsvzyCDrR3GjK58pvn20gFG8XW195mpuUY0hO38GQ~NfAnlrkYbg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Isoflurane modulates sub-threshold transient and persistent currents. (A) Representative currents recorded by a stair ramp protocol. Transient (INaT) and state-steady persistent (INaP) currents at each potential were calculated. (B) Sample of initial part of recording. INaT was inhibited by isoflurane at a clinically relevant concentration (0.42 mM, ~1.6 minimum alveolar concentration [MAC], n = 8, P = 0.047, and P = 0.011) at potentials of −50 and −45 mV (C), whereas INaP was inhibited at a potential of −60 mV (D, n = 9, P = 0.044). Data are mean ± SD. *P < 0.05 by two-way ANOVA. CTL, control; ISO, isoflurane.
