Fig. 2.
Intraperitoneal delivery of hydrogen-rich saline prevents remifentanil-induced postoperative hyperalgesia. The baseline numbers of paw withdrawal latency (PWL) (A) and paw withdrawal threshold (PWT) (B) were similar in all groups. When compared with rats receiving saline (sal), incision (inci) and remifentanil (remi) significantly increased PWL (C) and PWT (D), respectively, at 48 h after surgery. Moreover, incision–remifentanil (inci + remi) treatment significantly enhanced thermal and mechanical hyperalgesia induced by incision. Intraperitoneal delivery of hydrogen-rich saline (10 ml/kg) attenuated remifentanil- and incision-depended hyperalgesia. Hydrogen-rich saline in rats receiving saline had no effect on PWL and PWT. Results are expressed as mean ± SD for n = 6 rats and analyzed by the one-way ANOVA with Dunnett post hoc comparisons. #P < 0.01 vs. saline; *P < 0.01 vs. incision; &P < 0.01 vs. corresponding non–hydrogen-rich saline group.

Intraperitoneal delivery of hydrogen-rich saline prevents remifentanil-induced postoperative hyperalgesia. The baseline numbers of paw withdrawal latency (PWL) (A) and paw withdrawal threshold (PWT) (B) were similar in all groups. When compared with rats receiving saline (sal), incision (inci) and remifentanil (remi) significantly increased PWL (C) and PWT (D), respectively, at 48 h after surgery. Moreover, incision–remifentanil (inci + remi) treatment significantly enhanced thermal and mechanical hyperalgesia induced by incision. Intraperitoneal delivery of hydrogen-rich saline (10 ml/kg) attenuated remifentanil- and incision-depended hyperalgesia. Hydrogen-rich saline in rats receiving saline had no effect on PWL and PWT. Results are expressed as mean ± SD for n = 6 rats and analyzed by the one-way ANOVA with Dunnett post hoc comparisons. #P < 0.01 vs. saline; *P < 0.01 vs. incision; &P < 0.01 vs. corresponding non–hydrogen-rich saline group.

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