Fig. 6.
Deoxyribonuclease (DNase) I intervention against pulmonary neutrophil extracellular trap formation: quantification of citrullinated histone-3 (Western blot, A) and DNA (B) in bronchoalveolar lavage fluid (BALF) demonstrates a reduction in neutrophil extracellular traps with intratracheal DNase treatment. (C) No significant change in BALF cell count was detected (Mann–Whitney test). ns = not significantly different. (D) DNase treatment led to an attenuation in the decrement in compliance. *P = 0.001 versus vehicle (Mann–Whitney); †P < 0.005 versus vehicle (t test). N = 10 per group. Note that 1 kPa = 7.5 mmHg.