Fig. 1.
Location of residues (α carbon atoms displayed) relevant to anesthetic modulation on TM2 and TM3 from consensus structural alignment of 2LLY (light blue–nAChR α 4), 2LM2 (blue–nAChR β 2), 3RIF (pink–GluCl), 2VL0 (red–ELIC), and 3EAM (purple–GLIC) using the SAlign algorithm. Ovals denote the general consensus alignment of residues known to modulate anesthetic activity. Notice the misalignment of the residues from 2BG9 (torpedo nAChR–gray) in both TM2 and TM3.