Fig. 4.
Comparison of the levels of sedation induced by intraperitoneal administration of four combinations of the drugs: saline 1 h after saline (control group), saline 1 h after bumetanide (10 µmol/kg; bumetanide group), midazolam (20 mg/kg) 1 h after saline (saline + MDZ group), and midazolam 1 h after bumetanide (bumetanide + MDZ group). Latencies to righting were measured 15 and 30 min after the administration of the second drugs in postnatal days 4 (A and B), 7 (C and D), and 28 (E and F) rats. Values are expressed as mean and SEM. P4, P7, and P28 = postnatal days 4, 7, and 28. MDZ = midazolam. #####P = 0.002; ####P = 0.003; ###P = 0.004; and ##P = 0.006, respectively. P value <0.0083 (0.05/6) was considered statistically significant. N = 6 in each group.