Fig. 2.
Time course of bispectral index (BIS) values and calculated effect-site concentration of propofol (CeProp) and remifentanil (CeRem) from induction to discontinuation of these drugs. All individual values are shown; data are averaged for graphical representation with a moving average filter of 1-min duration. Median values (thick line) are presented with 10th and 90th percentiles (fine line). Auto: closed-loop control of propofol and remifentanil. Manual: manual group guided by the BIS.