American Society of Anesthesiologists

Fig. 2.

Ventilatory responses to 8% carbon dioxide (CO2) stimulus for 5 min (shaded area) in wild type (empty circles) and Phox2b27Alacki/+ (mutant) mice (filled circles) with selective loss of retrotrapezoid nucleus before anesthesia at postnatal day (P) 8 (n = 38 wild type and n = 36 mutant mice; A) and P14 to P16 (n = 69 wild type and n = 47 mutant mice; B). Breathing was measured by whole-body plethysmography. *P < 0.05, #P < 0.005, and †P < 0.0005 indicate significant differences between wild types and mutants. Data are mean ± SD.

Ventilatory responses to 8% carbon dioxide (CO₂) stimulus for 5 min (shaded area) in wild type (empty circles) and Phox2b^27Alacki/+ (mutant) mice (filled circles) with selective loss of retrotrapezoid nucleus before anesthesia at postnatal day (P) 8 (n = 38 wild type and n = 36 mutant mice; A) and P14 to P16 (n = 69 wild type and n = 47 mutant mice; B). Breathing was measured by whole-body plethysmography. *P < 0.05, #P < 0.005, and †P < 0.0005 indicate significant differences between wild types and mutants. Data are mean ± SD.

This Feature Is Available To Subscribers Only