Fig. 3. The area at risk (AAR) compared with left ventricular weight was similar among all groups (A) . Infarct size expressed as a percentage of the AAR was reduced by anesthetic preconditioning (APC), but the effect was eliminated after pretreatment with alloxan. *P < 0.05 versus  APC (B) . The release of troponin-I after 2 h of reperfusion indicates the magnitude of damage caused by ischemia-reperfusion. The magnitude of damage in the heart was larger in control, alloxan + APC, and alloxan groups than in the APC group. *P < 0.05 versus  APC. Mean ± SD, n = 8 per group (C) .