Fig. 7. Effects of halothane on the peak responses of carbachol- (1 mm) and subsequent KCl-evoked (100 mm) [Ca2+]cyttransients. (A, B ) Representative Ca2+-response traces ([Ca2+]cytvs. time) in the absence (A ) and presence (B ) of 0.25 mm halothane. (C, D ) Evoked peak [Ca2+]cyttransients in the presence of halothane (0.05–1 mm, ≈ 0.2–4 MAC) with additions of 1 mm carbachol (C ) and subsequent 100 mm KCl (D ). Values presented are mean ± SEM (n = 5–16). The significance of the difference between control and drug-treated groups was tested using the Dunnett test. *At least P < 0.05.