Fig. 2. The fractional plasma dilution based on hemoglobin (top) and albumin (bottom) during intravenous infusion of 25 ml/kg acetated Ringer’s solution over 30 min during thyroid surgery under isoflurane (left) or propofol (right) anesthesia. Fine lines represent individual patients, and thick lines represent simulated dilution–time profiles based on the mean kinetic parameter estimates as shown in table 2 .