Table 1. Effects of Bupivacaine Isomers on Oxidative Phosphorylation in Rat Heart Mitochondria
Experimental conditions are described in Materials and Methods. Basal, without ADP, and ADP-stimulated oxygen consumption rates supported by pyruvate are expressed in nmol oxygen · min−1· mg protein−1. Adenosine triphosphate (ATP) synthesis rate is expressed in nmol ATP · min−1· mg protein−1. ATP-to-oxygen ratio is calculated as the ratio of the rate of ATP synthesis to the rate of the concomitant respiration in the presence of ADP. Values are mean ± SD (n = 5).
*P < 0.05 versus control.
ADP = adenosine diphosphate; ATP = adenosine triphosphate; ATP/O = adenosine triphosphate to oxygen ratio.
