Fig. 7. Influence of the MEK/ERK1/2 MAP kinase inhibitor PD98059 on the anesthetic-induced relaxation. Force is expressed as a percentage of the control in mean ± SD (n = 3–9); [PD98059] (μm) = concentrations of the MEK inhibitor in μm; one of the anesthetic concentrations was present except at 0/0 (time control), in which neither anesthetic nor SB20358 was present; *P < 0.05 compared with that of the time control (0/0); #P < 0.05 compared with that of the anesthetic in the absence of PD98059 (0 μm).