Fig. 2. Effects of sevoflurane on L-type Ca²⁺currents in human atrial cardiomyocytes prestimulated with isoproterenol. Five traces from one experiment are superposed and recorded under basal conditions, after application of isoproterenol (1 μm), in the presence of sevoflurane (0.29 mm, 1 minimum alveolar concentration [MAC ]), after washout of sevoflurane but with isoproterenol still present, and also after washout of isoproterenol. The voltage protocol is shown in the inset. The currents are normalized to the capacitance of the cell (78 pF).