Fig. 3. Time course of calculated S -ketamine plasma concentrations after a constant-rate infusion of 5 μg · kg−1· min−1(shaded areas ). The calculation was based on a data sheet from the literature 58exemplary for a 75-kg subject ( A ) . Infusion of S (+)-ketamine resulted in a significant increase in the mean arterial pressure (MAP) (P < 0.05 by ANOVA); oxygen saturation measured by pulse oximetry (Spo2) and heart rate (HR) remained unchanged (P = NS by ANOVA) ( B ). Pain ratings (C ) and areas of punctate hyperalgesia (D ) were reduced significantly during infusion of S (+)-ketamine (P < 0.05 by ANOVA for each). Areas of touch-evoked allodynia ( E ) were not affected by S -ketamine (P = NS by ANOVA). Data are expressed as mean ± SD (n = 13), *P < 0.05, planned comparisons corrected with the Bonferroni procedure. NRS = numerical rating scale.
