Fig. 2. The effect site unit disposition functions obtained from the pharmacokinetic (PK)–pharmacodynamic (PD) parameters of Stanski and Maitre 7(solid curve ), the pharmacokinetic parameters of Stanski and Maitre and the ke0of Shanks et al. 8(naive method; dotted curve ), and the pharmacokinetic parameters of Stanski and Maitre and the ke0obtained from the tpeakof Shanks et al. (tpeakmethod; dashed curve , indistinguishable from the solid curve).