Fig. 1. The effect site unit disposition functions (i.e. , response to a 1-mg bolus dose) obtained from the pharmacokinetic (PK)–pharmacodynamic (PD) parameters of Shanks et al. 8(solid curve ), the pharmacokinetic parameters of Shanks et al. and the ke0of Stanski and Maitre 7(naive method; dotted curve ), and the pharmacokinetic parameters of Shanks et al. and the ke0obtained from the Stanski and Maitre tpeak(tpeakmethod; dashed curve , nearly indistinguishable from the solid curve).