Fig. 1. Solanaceous glycoalkaloids (SGAs) inhibit human acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The effects of varied SGA concentrations on the hydrolytic activity of human AChE (solid symbols) and BuChE (open symbols) are shown. Substrate hydrolysis activity was normalized and is presented as percentage of control. Inhibition by both α-solanine (circles) and α-chaconine (triangles) was concentration- dependent. Arrows denote the range of serum SGA levels after potato consumption. 9,10Data points are mean ± SEM of at least five experiments for each concentration. Determinations within each experiment were carried out in triplicate. Error bars not visible are within symbol size.