Fig. 1. Effects of midazolam and propofol on vascular endothelial growth factor (VEGF) concentration in rat plasma. Midazolam (•, 0.3 mg/kg) or propofol (▴, 10 mg/kg) was injected as a bolus and then midazolam (0.1 mg · kg−1· h−1) or propofol (10 mg · kg−1· h−1) was administered for 8 h to male Sprague–Dawley rats via an infusion pump. Each value represents the mean ± standard error (n = 3 propofol or 5 midazolam). *P is less than 0.05 compared with preinfusion concentration.