Table 2. Pharmacokinetic Parameters after Intravenous Infusion of γ-Hydroxybutyric Acid in Hypovolemic and Control Groups
Results are expressed as mean ± SD.
*P < 0.05, Mann–Whitney U test.
GHB =γ-hydroxybutyric acid (390 mg · kg−1· 5 min−1); Vmax= theoretical maximum rate of the elimination; KM= Michaelis–Menten constant; VC= volume of distribution of the central compartment; VT= volume of distribution of the peripheral compartment; VSS= total volume at steady-state; Cld= intercompartmental clearance; AUC0–420= area under the curve extrapolated from time 0 to 420 min.