Table 3. Pharmacokinetic–Pharmacodynamic Fitting Results for the Unbound Receptor Model

EC⁵⁰is a calculated value and not a model parameter; molecular-weight rocuronium = 609.69. Values are shown as median with range in parentheses.

β= exponential coefficient of twitch height–unbound receptor concentration relation; EC⁵⁰= rocuronium concentration at 50% effect; k^e0= rate constant between plasma and effect compartment; R^tot= total receptor concentration; URM = unbound receptor model.