![Fig. 1. Concentration-response curves to levcromakalim (10−8to 10−5m) in the absence and in the presence of glibenclamide (10−5m), obtained in the rat thoracic aorta with or without endothelium. Data are shown as means ± SD and expressed as percent of maximal relaxation induced by papaverine (3 × 10−4m; 100%= 1,060 ± 134 mg [n = 5] and 1,020 ± 305 mg [n = 5] for control rings with endothelium or rings treated with glibenclamide, 100%= 1,045 ± 91 mg [n = 4] and 1,030 ± 289 mg [n = 4] for control rings without endothelium or rings treated with glibenclamide, respectively). * Difference between control rings and rings treated with glibenclamide is statistically significant (P < 0.05).](https://asa2.silverchair-cdn.com/asa2/content_public/journal/anesthesiology/97/4/10.1097_00000542-200210000-00020/2/20ff1.png?Expires=1716495196&Signature=NrxX7730L6a15VuxZYhJlTdW7WtpiUeblI~RrXws2X42klpljBvOCp~iLOb7wGhQ7AVoBGd41MPHztEhDsodNaoww-y0Hv5xsxnYX3538ZqHZVN0XItGDuTut14iKpgaN8PXLXqzd-5~DDz6~QpCV14LA2Syhv3auezVFIsle52oM~p52~NFO-czkW3W4-VCZO1Lu~wuVRKY32iXj9JkSoIvhJkYzKhyWYlAoO-PMdm4gc2lyeVtH2f-V~ghl-MKd6N7nqUFUviWXs9iWb2WJ5Q0szmxQFoexN1CO5ct4rGZS0owUMrWoAIQ0B8hO3t5sTGuLkhUrlRQ1HPpmM5jIA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Fig. 1. Concentration-response curves to levcromakalim (10−8to 10−5m) in the absence and in the presence of glibenclamide (10−5m), obtained in the rat thoracic aorta with or without endothelium. Data are shown as means ± SD and expressed as percent of maximal relaxation induced by papaverine (3 × 10−4m; 100%= 1,060 ± 134 mg [n = 5] and 1,020 ± 305 mg [n = 5] for control rings with endothelium or rings treated with glibenclamide, 100%= 1,045 ± 91 mg [n = 4] and 1,030 ± 289 mg [n = 4] for control rings without endothelium or rings treated with glibenclamide, respectively). * Difference between control rings and rings treated with glibenclamide is statistically significant (P < 0.05).
