Fig. 4. Effects of Na+channel blocker tetrodotoxin (TTX, 1 μm) and local anesthetics (LAs) bupivacaine (BPV), ropivacaine (RPV), mepivacaine (MPV), and lidocaine (LDC) (2.3 mm for all) on 100 mm KCl-evoked (A ) or 1 mm CAB-evoked (B ) [Ca2+]itransients. Values presented are expressed as mean ± SEM (n = 3–59) and expressed as percentage of the control group (−) TTX (the first bar from the left). The significance of the differences among different groups was tested using Student-Neuman-Keuls test and labeled as follows:#P < 0.05 versus the control group without LA and TTX (the first bar from the left); $ P < 0.05 versus the TTX-control group without LA (the second bar from the left); n.s. = no significant difference was found between groups (±) TTX.