Fig. 3. Effects of ONO-AE1–329 on withdrawal threshold to mechanical stimulation on the arthritic side at the time points of 24 h (top ) and 4 weeks (bottom ) after injection of complete Freund's adjuvant. Closed circles, 50 μg; open circles, 25 μg; closed triangles, 10 μg; and open triangles, saline. Data are mean ± SD. N = 6 to 7 in each group. §P < 0.05 compared to control, *P < 0.05 compared to baseline, †P < 0.05 compared among groups.