Fig. 4. Cumulative creatine kinase (CK) release over 15 min of reperfusion after 4-h ischemia at 17°C and infarct size, determined as percent whole heart weight after 70 min of reperfusion, are shown. Anesthetic pretreatment reduced CK release below that of CON, and this effect was partially reversed by 5-HD. Infarct size was smaller after SPC, and this effect was reversed by 5-HD. †P < 0.05, SPC versus CON.