Fig. 3. Time course of d[Ca²⁺]/dt^minand dLVP/dt^minbefore, during, and after 4-h ischemia at 17°C in CON, SPC, and SPC + 5-HD groups. The d[Ca²⁺]/dt^mindecreased slightly during exposure to sevoflurane, increased during cooling, and was much lower during hypothermic ischemia in each group. On reperfusion, d[Ca²⁺]/dt^minwas greater than baseline in SPC and SPC + 5-HD groups and much greater than in the CON group. The dLVP/dt^mindecreased during exposure to sevoflurane and was nil during ischemia; on reperfusion, dLVP/dt^mingradually increased during reperfusion in each group, but was greater in SPC groups than in the nontreated CON group.