American Society of Anesthesiologists

Fig. 3. The effects of sodium phosphate buffer pH on contractile forces induced by 3 × 10−5m norepinephrine pretreated with 10−4m peroxynitrite (ONOO−1). After treated norepinephrine (0.1 ml) was added to an organ chamber containing 30 ml Krebs Henseleit solution, the final concentration of the norepinephrine was 10−7m. Control: 3 × 10−5m norepinephrine pretreated with 10−4m decomposed ONOO−1at pH 7.4. Data are expressed as mean ± SD of eight experiments. There were significant statistical differences versus control (P < 0.05). *P < 0.05 compared with pH 7.4.

Fig. 3. The effects of sodium phosphate buffer pH on contractile forces induced by 3 × 10⁻⁵m norepinephrine pretreated with 10⁻⁴m peroxynitrite (ONOO⁻¹). After treated norepinephrine (0.1 ml) was added to an organ chamber containing 30 ml Krebs Henseleit solution, the final concentration of the norepinephrine was 10⁻⁷m. Control: 3 × 10⁻⁵m norepinephrine pretreated with 10⁻⁴m decomposed ONOO⁻¹at pH 7.4. Data are expressed as mean ± SD of eight experiments. There were significant statistical differences versus control (P < 0.05). *P < 0.05 compared with pH 7.4.

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