Fig. 1. Effects of various blood products on lipopolysaccharide-stimulated cytokine response of cultured human whole blood. Venous blood samples (recipient, n = 5 each) were coincubated with equal amounts of allogeneic fresh or allogeneic stored whole blood (A ), allogeneic stored whole blood with or without prestorage leukodepletion (B ), allogeneic and autologous stored whole blood without (C ) and with (D ) prestorage leukodepletion, and stored whole blood or packed erythrocytes (E ), respectively. Box plots represent the 25th/75th percentile, median and range. *P < 0.05 as compared with controls corrected for dilution; #P < 0.05 between the different blood products. IL = interleukin; LPS = lipopolysaccharide; TNF = tumor necrosis factor.