American Society of Anesthesiologists

Fig. 3. (A ) Effect of ketamine on lemakalim-induced vasorelaxation in endothelium-intact (E+) pulmonary arterial rings. Ketamine (5 × 10−5, 10−4m) attenuated (*P < 0.05) lemakalim-induced relaxation compared with rings without ketamine. Ketamine (10−4m) also attenuated (#P < 0.05) maximal vasorelaxation induced by lemakalim. (B ) Effect of ketamine on lemakalim-induced relaxation in endothelium-denuded (E−) pulmonary arterial rings. Ketamine (5 × 10−5, 10−4m) attenuated lemakalim-induced vasorelaxation (IC50:*P < 0.05; Rmax:#P < 0.05).

Fig. 3. (A ) Effect of ketamine on lemakalim-induced vasorelaxation in endothelium-intact (E+) pulmonary arterial rings. Ketamine (5 × 10⁻⁵, 10⁻⁴m) attenuated (*P < 0.05) lemakalim-induced relaxation compared with rings without ketamine. Ketamine (10⁻⁴m) also attenuated (#P < 0.05) maximal vasorelaxation induced by lemakalim. (B ) Effect of ketamine on lemakalim-induced relaxation in endothelium-denuded (E−) pulmonary arterial rings. Ketamine (5 × 10⁻⁵, 10⁻⁴m) attenuated lemakalim-induced vasorelaxation (IC⁵⁰:*P < 0.05; R^max:#P < 0.05).

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