Fig. 2. (A ) Effect of etomidate on lemakalim-induced vasorelaxation in endothelium-intact (E+) pulmonary arterial rings. Etomidate attenuated (*P < 0.05) lemakalim-induced vasorelaxation compared with rings without etomidate. Etomidate (5 × 10⁻⁵m) also attenuated (#P < 0.05) the maximal relaxation response (R^max) to lemakalim. (B ) Effect of etomidate on lemakalim-induced relaxation in endothelium-denuded (E−) pulmonary arterial rings. Etomidate (5 × 10⁻⁶m) did not alter lemakalim-induced vasorelaxation (IC⁵⁰) compared with rings without etomidate, but etomidate (5 × 10⁻⁵m) attenuated (#P < 0.05) maximal relaxation induced by lemakalim.