Fig. 4. Paw withdrawal latency (percent of preanesthetic values, mean values ± SD) in forelimbs (black bars) and hind limbs (gray bars). Nociceptive withdrawal hyperreflexia was induced with intraperitoneal pentobarbital (30 mg/kg). There was a concentration-dependent reduction of hind limb hyperreflexia with acetazolamide (A;P = 0.002, interaction term 2-way analysis of variance). *P < 0.01 relative to upper limb values. E = ethoxyzolamide.