Fig. 3. The effects of lumbar intrathecal pretreatment with 10 μl ethoxyzolamide, 50 μm, on the time course of PWL and sedation scores after intraperitoneal injection of (A ) 1.9 mg/kg midazolam (n = 6 animals), (B ) 30 mg/kg pentobarbital (n = 8 animals), or (C ) 50 mg/kg propofol (n = 8 animals). The mean PWL during the 55-min observation period was longer in the lower limbs (filled symbols) than in the upper limbs (empty symbols) for midazolam and pentobarbital but not for propofol (see table 3for details of analysis).