Fig. 2. The effects of lumbar intrathecal pretreatment with 10 μl acetazolamide, 20 μm, on sedation scores and PWL after intraperitoneal injection of (A ) 1.9 mg/kg midazolam (n = 5 animals), (B ) 30 mg/kg pentobarbital (n = 12 animals), or (C ) 50 mg/kg propofol (n = 7 animals). The mean PWL during the 55-min observation period was longer in the lower limbs (filled symbols) than in the upper limbs (empty symbols) for all three sedative drugs (see table 3for details of analysis).