Fig. 3. (A ) Typical thermodilution and (B ) dye-dilution curves at the inlet of the brain (measured in the aorta) and the outlet of the brain (measured in the jugular bulb). The thermodilution curve in the jugular bulb is significantly delayed and damped because of distribution in the extravascular brain tissue, whereas the indocyanine green dye-dilution curve in the jugular bulb was only slightly delayed. The typical recirculation peak of the intravascular indicator is visible in both dye-dilution curves.