Fig. 2. Dose-dependent effect of isoflurane on unstimulated and agonist-induced (2 μm ADP; 6 μm TRAP-6) expression of CD62P on the platelet surface membrane. Data are presented as percentage of platelets positive for CD62P (A  and B ) and the mean fluorescence intensity (MFI) of expressed CD62P in arbitrary units (C  and D ). CD62P MFI represents the amount of CD62P epitopes expressed on the surface membrane per single platelet. Box plots show 25th and 75th percentiles, median, and range of 10 independent experiments for each concentration of isoflurane. *P < 0.05, #P < 0.01 compared with control in the absence of isoflurane.

Fig. 2. Dose-dependent effect of isoflurane on unstimulated and agonist-induced (2 μm ADP; 6 μm TRAP-6) expression of CD62P on the platelet surface membrane. Data are presented as percentage of platelets positive for CD62P (A  and B ) and the mean fluorescence intensity (MFI) of expressed CD62P in arbitrary units (C  and D ). CD62P MFI represents the amount of CD62P epitopes expressed on the surface membrane per single platelet. Box plots show 25th and 75th percentiles, median, and range of 10 independent experiments for each concentration of isoflurane. *P < 0.05, #P < 0.01 compared with control in the absence of isoflurane.

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