Fig. 4. Effects of anesthetics on 5-hydroxytryptamine (5-HT)–induced currents at different membrane potentials ranging from −90 to +30 mV. The percentages of the control currents were plotted. (A ) 1 μm 5-HT with 2% sevoflurane. (B ) 1 μm 5-HT with 70% N2O. (C ) 1 μm 5-HT with 70% Xe. No significant difference (P > 0.05 vs. percent of control current at −70 mV) was found at different membrane potentials, showing no voltage dependency. Data from more than five oocytes were expressed as mean ± standard error of the mean.