Table 1. Comparison of the Cutaneous Analgesic Duration and Effectiveness of Amitriptyline and Bupivacaine with and without Epinephrine

All values are expressed as mean ± SE, except for fractions. Duration of complete block for amitriptyline is blank because the mean maximum possible effect of all the animals in the respective groups was less than 100%.

*P < 0.05 when the area under the curve (AUC) for amitriptyline is significantly more than the same concentration of bupivacaine in the corresponding with–without epinephrine group only.

†P < 0.05, t  test comparison with and without epinephrine.

‡P < 0.05, chi-square test with and without epinephrine.