Figure 1. Schematic diagrams of the experimental protocols employed in the two groups of animals investigated. Control data were collected for a minimum of 30 min. The first group of animals investigated in this study were administered low bolus doses of 4-chloro-m-cresol, and in the second group of animals larger doses were used. Provided are the bolus concentrations in [micro sign]M and mg/kg concentrations and the equivalent cumulative dose values. The shaded areas indicate the times during which the bolus doses were administered. The larger bolus doses were administered over a 10-min period to minimize associated cardiovascular instability induced by the 4-chloro-m-cresol administration. The times at which blood samples were withdrawn (S) are indicated below each timeline.