Fig. 3. (A ) Plots of ΔThreshold against time after soya emulsion control (filled circles), 25 mg/kg anandamide (AEA; open circles), coadministration of 25 mg/kg anandamide with 1 mg/kg SR141716A (filled triangles), or 1 mg/kg SR144528 (open triangles). (B ) Corresponding mean areas under the curve (AUC) of ΔThreshold versus  time plots. The area under the curves for 25 mg/kg anandamide alone and when coadministered with 1 mg/kg SR144528 are both significantly different from soya emulsion control (*each n = 5, ANOVA, Dunnett, P < 0.05).

Fig. 3. (A ) Plots of ΔThreshold against time after soya emulsion control (filled circles), 25 mg/kg anandamide (AEA; open circles), coadministration of 25 mg/kg anandamide with 1 mg/kg SR141716A (filled triangles), or 1 mg/kg SR144528 (open triangles). (B ) Corresponding mean areas under the curve (AUC) of ΔThreshold versus  time plots. The area under the curves for 25 mg/kg anandamide alone and when coadministered with 1 mg/kg SR144528 are both significantly different from soya emulsion control (*each n = 5, ANOVA, Dunnett, P < 0.05).

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