Fig. 2. (A ) Plots of ΔThreshold against time after dimethyl sulphoxide (DMSO):saline control (filled circles), 10 mg/kg palmitoylethanolamide (filled triangles), and 25 mg/kg palmitoylethanolamide (open circles). A negative deflection of this curve reflects a referred hyperalgesia to the hind limb. (B ) Corresponding mean areas under the curve (AUC) of ΔThreshold versus  time plots. Both doses of palmitoylethanolamide (PEA) are significantly different to DMSO:saline control (*n = 5, ANOVA, Dunnett, P < 0.05).

Fig. 2. (A ) Plots of ΔThreshold against time after dimethyl sulphoxide (DMSO):saline control (filled circles), 10 mg/kg palmitoylethanolamide (filled triangles), and 25 mg/kg palmitoylethanolamide (open circles). A negative deflection of this curve reflects a referred hyperalgesia to the hind limb. (B ) Corresponding mean areas under the curve (AUC) of ΔThreshold versus  time plots. Both doses of palmitoylethanolamide (PEA) are significantly different to DMSO:saline control (*n = 5, ANOVA, Dunnett, P < 0.05).

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