Fig. 2. Quality of fit of the measured serum concentrations to those predicted from our published pharmacokinetic model, which assumes dissolution of suppositories is a zero-order process and absorption is a first-order process. The y  axis displays the ratio of measured concentrations to those predicted from our published pharmacokinetic analysis. Solid lines represent values resulting from the initial 40-mg/kg dose. Dashed lines represent values resulting from subsequent 20-mg/kg doses at 6-h intervals. Six patients received only the initial 40-mg/kg dose.