Fig. 3. Dideoxyforskolin decreases d-aspartate release from astrocytes after tert-butyl hydroperoxide (t-BOOH)–induced oxidative stress. Astrocytes were preloaded with d-[³H]aspartate (10 μm) overnight. Subsequently, beginning at time zero of efflux, they were incubated with t-BOOH (1 mm) or aqueous vehicle for 30 min at 37°C. Next, they were incubated with 1,9-dideoxyforskolin (DDF; 100 μm) or drug vehicle (dimethylsulfoxide) for an additional 90-min period at 37°C. Plotted are cumulative efflux rates after 60 min for four experiments. * P  less than 0.05 compared with the vehicle control that did not receive t-BOOH.