Figure 4. Observed and predicted [Greek small letter epsilon]-aminocaproic acid (EACA) concentrations for two patients with renal failure. Note that the best model fit from patients without renal failure (indicated with a dashed line) overestimates the actual concentration achieved after the loading dose, consistent with an increased volume of distribution, but underestimates the EACA concentration later, consistent with reduced EACA clearance in renal failure. Solid lines = individual model fits to a one-compartment model (see Table 2for details).