Fig. 2. The effect of bicuculline on the initial response after the first electrical stimulus of the train and the final response after 16 consecutive electrical stimuli (0.5 Hz) measured in the C-fiber and postdischarge latencies (90–800 ms) in rats with spinal nerve ligation–induced neuropathy (circles) and sham-operated (triangles) and nonoperated control animals (squares). Mean of the effect achieved 20 min after intrathecal (i.t.) administration of bicuculline (± SEM) is plotted against the respective dose. Numbers of cells recorded after each bicuculline dose are the same as in figure 1. Asterisk indicates statistically significant difference between the study groups.